Reduced diffusion in acute cervical cord multiple sclerosis lesions
نویسندگان
چکیده
منابع مشابه
Acute demyelinating lesions with restricted diffusion in multiple sclerosis.
BACKGROUND AND OBJECTIVES It is widely accepted that typical acute demyelinating lesions in relapsing-remitting multiple sclerosis (RRMS) exhibit vasogenic edema with increased diffusion, as demonstrated by an increased apparent diffusion coefficient on MRI. In contrast, acute ischemic lesions demonstrate cytotoxic edema with restricted diffusion. Recent reports have documented selected cases o...
متن کاملInvestigation of apparent diffusion coefficient and diffusion tensor anisotrophy in acute and chronic multiple sclerosis lesions.
BACKGROUND AND PURPOSE The various stages of multiple sclerosis (MS) are characterized by de- and remyelination as well as by inflammation. Diffusion MR imaging is sensitive to tissue water motion, which might correspond to these pathologic processes. Our purpose was to demonstrate differences in apparent diffusion coefficient (ADC) and diffusion tensor anisotropy in acute and chronic MS plaque...
متن کاملMitochondrial defects in acute multiple sclerosis lesions
Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the CNS. The structural and immunopathological patterns of demyelination suggest that different immune mechanisms may be involved in tissue damage. In a subtype of lesions, which are mainly found in patients with acute fulminant multiple sclerosis with Balo's type concentric ...
متن کاملAxonal damage in acute multiple sclerosis lesions.
One of the histological hallmarks of early multiple sclerosis lesions is primary demyelination, with myelin destruction and relative sparing of axons. On the other hand, it is widely accepted that axonal loss occurs in, and is responsible for, the permanent disability characterizing the later chronic progressive stage of the disease. In this study, we have used an antibody against amyloid precu...
متن کاملGrey matter involvement by focal cervical spinal cord lesions is associated with progressive multiple sclerosis.
BACKGROUND The in vivo relationship of spinal cord lesion features with clinical course and function in multiple sclerosis (MS) is poorly defined. OBJECTIVE The objective of this paper is to investigate the associations of spinal cord lesion features on MRI with MS subgroup and disability. METHODS We recruited 120 people: 25 clinically isolated syndrome, 35 relapsing-remitting (RR), 30 seco...
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ژورنال
عنوان ژورنال: Neurology: Clinical Practice
سال: 2016
ISSN: 2163-0402,2163-0933
DOI: 10.1212/cpj.0000000000000309